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Alcohol abuse can lead to vitamin B12 deficiency due to the following reasons: Alcohol consumption can reduce B-12 absorption as chronic alcohol consumption can lead to gastritis (inflammation of the stomach lining) and impair the production of intrinsic factor, which is a protein necessary for the absorption of vitamin B12

doi: 10.1046/j.1525-1497.2001.03419.x 555 NatelsonBH

It has shown promising results in obesity research , enhancing fat oxidation and improving lipid profiles while preserving lean muscle mass

Beyond 6 months , ongoing maintenance therapy prevents recurrence of deficiency

The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose