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Route of Administration: Oral gavage, subcutaneous injection, intraperitoneal injection each route has distinct implications for absorption, bioavailability, and systemic exposure
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The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years
If you've been taking oral B12 supplements without feeling a difference, a shot is the most reliable way to find out whether the issue is your B12 levels or something else
