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Science 341(6147):800802 Hankir MK et al (2017) Gastric bypass surgery recruits a gut PPAR-alpha-striatal D1R pathway to reduce fat appetite in obese rats

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GLP-1 (Glucagon-Like Peptide-1) is a gut-derived incretin hormone that regulates postprandial insulin secretion and inhibits glucagon release

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The V max and K m of PDEs were not significantly altered- even in the presence of a very high concentration of CoQ 10 H 2 (100 M)- compared to IBMX, a nonselective competitive PDE inhibitor (Fig