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GLP-1 receptor agonists are generally contraindicated in pregnancy and breastfeeding, and some have specific restrictions in severe renal impairment

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Peptides improve metabolic efficiency and reduce systemic inflammation, which creates the internal environment for hormone production to stabilize

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found that long-chain inulin-type fructans enhanced expression of the intestinal-barrier TJ proteins occludin and claudin-2, antimicrobial peptides -defensin-1, cathelicidin-related antimicrobial peptide, and SCFAs production (55)