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[71] [72] Lisdexamfetamine's therapeutic effects for BED primarily involve direct action in the central nervous system after conversion to its pharmacologically active metabolite, dextroamphetamine

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(2015) found that AS-IV improved the cardiac hemodynamics, mediated energy biosynthesis, and upregulated ATP5D and PGC-1 expression in Iso-induced cardiac injury

Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

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