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While exact published numbers from SURMOUNT-5 continue to influence clinical practice, the general pattern confirms that tirzepatide at all doses produces greater weight reduction than even maximum-dose semaglutide

However, chronic acid reflux, occurring more than twice a week, may indicate GERD

The median follow-up duration was 41.8 months

Tolerance: Gradual dose escalation helps monitor side effects and ensures patient comfort

251,252 Additionally, miR-27a downregulation in SONFH models was found to impair BMP-2 and Runx2 expression while increasing caspase-3/9 activity and Bax expression