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In addition, Notch signaling mediates G1/S cell cycle progression through overexpression of Cyclin D3 and CDK4 in T cells (Joshi et al., 2009) and through reduction of p27 KIP1 , leading to more rapid cell cycle progression in T-cell acute lymphoblastic leukemia cells (Dohda et al., 2007)

Again, LPS stimulation significantly reduced the expression of these NP markers, particularly in the NP and 293T cocultures

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