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The authors conducted a two-year observational study that explored changes in body weight, cardiometabolic and endocrine parameters in obese women with PCOS who continued taking metformin after stopping semaglutide

To evaluate aging, the researchers relied on several "epigenetic clocks." These tools estimate biological age by measuring DNA methylation, a pattern of chemical tags that influences how genes are switched on or off without changing the DNA sequence itself

Li-Huei Tsais group found that cells carrying the variant run their phospholipid pathway poorly and extra choline reversed the defect, a low-risk and mechanism-based option for carriers even though the targeted human trials are not yet in

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