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doi: 10.1172/jci.insight.123182 172 LiuZ.RenZ.ZhangJ.ChuangC.-C.KandaswamyE.ZhouT.et al

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A product may demonstrate: Better stability in a laboratory Higher blood levels after a dose Increased glutathione in selected cells Changes in an oxidative-stress biomarker Those findings can be meaningful, but they do not automatically prove that the product: Improves energy or cognition Prevents cardiovascular or neurodegenerative disease Detoxifies the body in a clinically meaningful way Treats chronic illness Slows biological aging Improves longevity Those larger claims require controlled clinical trials measuring patient-important outcomes