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Patients with multiple high-risk variants often see better long-term outcomes with extended GLP-1 use, while those with fewer genetic risk factors may achieve durable results with temporary treatment plus lifestyle modification

However, it is important to note that the study follow-up was only 12 weeks, and long-term effects remain uncertain

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Researchers also face the challenge of confounding variables, since many GLP-1 users have diabetes, obesity, and high blood pressure simultaneously, all of which independently raise the risk of eye disease

Kim JW, Jeon YJ, Jang MJ, Kim JO, Chong SY, Ko KH, Hwang SG, Oh D, Oh J, Kim NK