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Beyond its classical function in reactive oxygen species detoxification, SRXN1 also modulates redox-sensitive signaling pathways that govern inflammation, apoptosis and cell survival, making it an essential component of cellular defense against oxidative stress-related damage
GLP-1 receptor agonists happen to address all three of these dimensions simultaneously
Metabolic stress activates immune cells, such as macrophages and neutrophils, in metabolic organs, including adipose tissue, the liver, the pancreas, and blood vessels (203)
Both factors could potentially quantitatively impact the binding of [ 68 Ga]Ga-DO3A-Tuna-2 in the liver
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