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Epigenetic dysregulation in IR Recent studies have suggested that epigenetic modifications such as DNA methylation (DNAm) and histone post-translational modifications (PTM) are implicated in the development of systemic IR

Nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH 2 ) are generated by the TCA cycle and beta-oxidation, respectively (Schwarz et al., 2014)

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