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These receptors are coupled to inhibitory G-proteins (G i/o ), which inhibit adenylyl cyclase, deplete cyclic AMP (cAMP) levels, and suppress neuronal firing by opening potassium channels

The thr92Ala 5 Type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormonestimulation test: A pharmacogenomic study