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2021;9:e00812

In summary, this section systematically elucidates the mechanisms through which glucotoxicity and lipotoxicity impact pancreatic -cell function and survival, leveraging both literature and experimental evidence to underscore the potential application of PCs in mitigating these pathological processes

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In examining the potential effects of race on GLP-1 M responsiveness, subjects self-identifying as Asian showed a lower average reduction in HbA1C compared to non-Asian subjects, indicating potentially less benefit from GLP-1 M treatment for glucose control in Asian populations (Tables 4 and 5, Fig