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However, Retatrutide is investigational and won't be available until 2027-2028, while Semaglutide is FDA-approved with 5+ years of proven safety data

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= 0.017) between fatigue scores and TSH, which led to underestimation of the simple correlation between S-5-HT and fatigue scores (without TSH as a covariate, rho = -0.24 Sig

However, addressing challenges like adherence, persistence, and patient empowerment is critical for manufacturers seeking to establish clinical credibility and align with the emerging models of care