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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)

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The phylogenetic tree was constructed by ClustalX version 1.81 and MEGA version 5, with a p -distance distribution, pairwise deletion, and bootstrap analysis of 10,000 repeats