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5e), which resulted in lower tumor burden and longer survival compared to mice treated with control CAR T cells (Figs

In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)

The Centers for Disease Control and Prevention (CDC) advises that any changes in the appearance of injectable medications could indicate spoilage or contamination

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