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From there the Harding lab built a series of metabolically stabilized angiotensin IV analogs, including an antagonist called Norleual, before arriving at dihexa, a stable, brain-penetrant descendant engineered to last in the body and reach the brain

Deletion of GIP receptor has been found to counteract high-fat diet induced weight gain in mice, suggesting a causal role of GIP in development of obesity [36]

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