, , .
Acute otitis media (middle ear infection) affects the eustachian tube's ability to equalize pressure, making chewing motions particularly painful due to increased pressure changes
It is associated with a wide range of clinical complications, such as cardiovascular diseases (e.g., ischemic heart disease and heart failure), metabolic disorders like type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnoea syndrome, knee osteoarthritis, mental health disorders, and certain types of cancer [2, 3]
However, in pathological conditions, excess NO can react with superoxide to form ONOO , a potent oxidant that can nitrate tyrosine residues in proteins and damage lipids and DNA [52]
This initiative is timely: the global market for GLP-1 obesity and diabetes drugs is exploding (projected ~USD 62 billion in 2025 to ~USD 157 billion by 2035 ( [7] ), with forecasts of ~$200 billion by 2030 ( [8] ) and tens of millions of patients on GLP-1s by the end of the decade)
