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Standalone B12 is appropriate for vegans, older adults, those with pernicious anaemia or malabsorption disorders, people taking metformin or proton pump inhibitors, and anyone with confirmed B12 deficiency on blood tests

However, there are a few things to keep in mind: Zinc Levels: Some studies suggest that long-term, high-dose supplementation may lower zinc levels

This stands in stark contrast to growth hormone, which typically worsens insulin sensitivity during treatment

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This side effect seems to be unique to GLP-1s, connected mostly to how they work in the brain