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The decreasing levels of NAA may also imply that there is a decrease in the total number of mitochondria since NAA is produced by energy-dependent reactions inside mitochondria, and there have been no mechanisms identified for upregulation of NAA synthesis when its concentration decreases (Schweinsburg et al

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TCP-1, a peptide discovered by Li et al., specifically targets blood arteries in tumor tissues [131]

Similarly, individuals with a family history of multiple endocrine neoplasia syndrome type 2 (MEN2) should not use these medications due to inherited thyroid cancer risk

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