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When IGF1 binding to IGF-IR/InsR is blocked by the anti-IGF-IR mAb cixutumumab, IGF1 binding to integrin v3 increases, resulting in activation of v3 and its downstream effectors Src, FAK, and PI3K, which confers cixutumumab resistance [172]

I do not know of anyone who has had to have an amputation due to numbness or pins and needles from B12 deficiency

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The primary role of the thalamus is to transfer sensory information between the peripheral nervous system and multiple cortical areas, including the sensory and visual cortices 4