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91 While preclinical data support the concept that mTOR inhibition can overcome insulin stimulation of breast cancer, 92 the combination of anti-IGF-1R with mTOR inhibitors (Table 1) to suppress further signaling 93 has proven to be too toxic to pursue

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Proc Natl Acad Sci USA 92 : 10281032 Girnita A, Girnita L, Prete Fd F, Bartolazzi A, Larsson O, Axelson M (2004) Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth

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