Trump, who has a history of commenting on peoples appearance, asked the officials who joined him in the Oval Office whether they had used the weight-loss medications
GLP-1 receptor agonists provide important cardiometabolic benefits, particularly for weight management, glycemic control, renal protection, and reduction of atherosclerotic cardiovascular risk, although their direct effects in established heart failure remain less certain
335 Moreover, androgens decrease the type I muscle fibers (TIMF) with highly oxidative and insulin-sensitive properties, while increase type II muscle fibers (TIIMF) that are glycolytic and less insulin-sensitive, further decreasing glycogen synthase expression and favoring the development of IR in PCOS
More on my personal experience here
The "failure" part means you either didn't lose weight, or you lost weight and regained it