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Even if GLP-1 monotherapy is found to be less effective for opioid cessation than a combination therapy, it has the potential to reach vastly more patients and reach them at earlier stages, including the high percentage of patients who have refused existing medication options

And why telehealth programs now outperform traditional clinics on nearly every metric that matters

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As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life (58, 59)