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Adipose vs Other NNMT Research Contexts While adipose is the most-developed NNMT-inhibition research application, NNMT biology has been studied in other contexts too: 5-Amino-1MQ as a tool compound has utility across these contexts, but adipose research is currently the deepest and most-established application area

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Small-Molecule NNMT Inhibitors: StructureActivity Relationships

As was noted for DNMT1 and PRMT3, sigmoidal dose-response curves and reliable estimates of IC 50 values could not be obtained since no significant inhibition was observed at the tested NNMT inhibitor concentrations