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Exhibit 2 Require DSNPs to Become Fully Integrated Dual Eligible Special Needs Plans (FIDE SNPs) : FIDE SNPs are a special type of DSNP that must coordinate and be at risk for coverage of both Medicare and Medicaid services, including LTSS, in return for a capitated payment

79 Chronic hyperglycemia activates mTORC1 and reduces mTORC2 activity 157 in islet cells, which leads to the translocation of FOXO1 to nucleus and less nuclear PDX1, resulting in reduced insulin synthesis and secretion and impaired cell mass 80,158 (Fig

Moshirfar M, Somani SN, Shmunes KM, Ronquillo YC

Liver Support and Protection NAC is widely used in medical settings to treat liver toxicity

Precomputed signatures for CMAP were available for 1288 drugs