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Methodologically, most fertility cohorts combine modest sample sizes with high dimensionality, heterogeneous endpoints, and partially missing omics blocks

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CTLA4 gene polymorphisms (+49A/G, CT60 A/G) are not linked to disease susceptibility, but experimental models show that CTLA4 blockade reduces ectopic lesion growth by inhibiting Treg-derived IL-10 and TGF- ( 2.2.3 Autoimmune overlaps Endometriosis exhibits autoimmune-like features, including autoantibodies to endometrial antigens and polyclonal B-cell activation ( vs

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