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For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

It plays a crucial role in detoxification, immune function, and protecting cells from oxidative damage

WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting atg125-16L1

Significant progress has been made in targeting this oncogenic driver, exemplified by the FDAs approval of two covalent inhibitorssotorasib (AMG510) in 2021 and adagrasib (MRTX849) in 2022 13,14

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