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DIPEA (36 ) and isobutyl chloroformate (13 ) were added by syringe in tandem into a solution of tubulysin B (82 mg) in anhydrous EtOAc (2.0 mL) at -15 C

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Pertussis toxin is given intraperitoneally (1 g/rat) to enhance the organ- specific autoimmunity

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