Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
up to 5 ml undiluted Direct IV injection Doses up to 10 ml administered slowly over 3 minutes Intraperitoneal injection Primary route in rodent preclinical studies Common Model Organisms Cerebrolysin has been studied across multiple species and model systems: Rats Primary preclinical model (Wistar, Sprague-Dawley strains)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Mintz K.T., Gammer B., Khan A.J., Shaub G., Levine S., Sisti D