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doi: 10.26355/eurrev_202102_25077 223 TgelFWeissKYangYHuZZhangPWestenfelderC

Given that Glu is primarily neuroactive while Gln is storable and neuroinactive, the Gln/Glu ratio can reflect the efficiency of Glu uptake by astrocytes and its conversion to Gln, which is crucial for regulating excitatory neurotransmission [20]

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In parallel with the development of 1 H-MRS methods, other MRS methods measuring active stable (non-radioactive) isotopes, including 13 C and 2 H, have been developed that specifically measure flux and mitochondrial energy production