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13 The latest meta-analysis shows that AN adult patients have an average reduction of 0.16 kg in whole-body bone mineral content, 14 and there is no gender difference in the reduction of BMD in adolescent patients, 15 In terms of bone microstructure, abnormalities are observed in the distal radius and distal tibia of AN patients, manifested as reduced volumetric bone mineral density (vBMD), decreased cortical bone area and thickness, increased porosity, decreased trabecular bone density and increased separation degree, but the results of studies on trabecular bone number changes are inconsistent

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Patients taking any prescription medications must consult their prescribing physician before initiating berberine supplementation to avoid severe adverse interactions

For instance, chronic alcohol use can alter the bodys response to anaesthesia, requiring higher doses for effectiveness and increasing the risk of complications

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