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6 Mechanisms of intestinal-brain signaling The gut-brain axis is a bidirectional communication system linking the gastrointestinal (GI) tract and the central nervous system (CNS), which plays a pivotal role in maintaining homeostasis across many physiological processes (Arneth, 2018

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The 2013 Endocrinology botulinum-construct paper (PMID 23825127) and the 2009 Sackmann-Sala IGF-axis paper (PMID 19386527) extend the comparative-mechanism framing into receptor-targeting and downstream-IGF analytical work

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