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The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)

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Bavachinin, a natural compound from Fructus Psoraleae, has been shown to reduce lipid accumulation in NAFLD by promoting fatty acid oxidation and inhibiting the cholesterol synthesis enzyme Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), while also enhancing cell proliferation through its facilitation of the interaction between PCNA and DNA polymerase delta

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Stability and Storage Differences Understanding stability characteristics helps preserve potency and guides product selection