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doi: 10.3389/fphar.2024.1439536 Received 13 June 2024 Accepted 19 September 2024 Published 08 October 2024 Volume 15 - 2024 Edited by Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia Reviewed by Lourdes Franco, Faculty of Medicine.University of Extremadura, Spain Jolanta Orze-Gryglewska, University of Gdansk, Poland Updates Copyright 2024 Mu, Qu, Yin, Wang, Liu and Liu

Overall, intentional weight loss in older adults appears safe, and may provide benefit to physical function, disability, QoL and cardiometabolic outcomes, when done under supervision of clinicians

Specific groups of people need to take vitamin B12 shots, such as Vegetarians and Vegans, older adults, individuals with gastrointestinal conditions, people with pernicious anaemia, pregnant and breastfeeding women, and individuals with symptoms of deficiency

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Both compounds require precise weekly dosing rather than daily administration