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Further experiments found that low-dose berberine can promote cell survival and antioxidant effects by up-regulating PI3K/AKT/Bcl-2 and Nrf2/HO-1 signal pathways

Importantly, the majority of these experimental findings have been further corroborated in human NS workers, with clear differences compared to day workers observed across multiple biological mechanisms (including oxidative stress, immune dysfunction, inflammation, melatonin disruption, clock gene alterations, epigenetic changes, telomere attrition, and hormonal imbalances)

Currently, several senolytics were reported to kill senescent cells ( In this study, we tested the hypothesis that FOXO4-DRI treatment can selectively remove senescent cells in expanded human chondrocytes, thus enhancing their potential to generate high-quality cartilage

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