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The most common side effects are gastrointestinal symptoms including nausea, vomiting, diarrhoea, and constipation, which are typically mild to moderate and improve with dose titration

Glucose concentrations were also not affected by sitagliptin treatment

The GIP receptor component may enhance insulin sensitivity and support fat metabolism

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A broader narrative review published in 2024 also concluded that IV glutathione is associated with serious safety concerns including anaphylaxis and hepatotoxicity , and stressed that there is insufficient evidence to recommend IV use for cosmetic skin lightening