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JAMA 2013

Could dosages be reduced while maintaining benefits

However, when ROS is produced at a higher concentration than antioxidants, pathological conditions such as oxidative stress and the associated diseases occur

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In contrast, the attempted deletion of the sll1545 gene invariably generated Km r clones carrying two types of chromosomes, mutant ( sll1545 :Km r ) and WT ( sll1545 + ) irrespectively of the duration of growth in the presence of Km used for selection (Figure 1B, see the 941 bp and 355 bp PCR products characteristic of, respectively, sll1545 :Km r and sll1545 + chromosomes)