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Given the multi-systemic mechanisms of berberine and alpha lipoic acid, this combination may offer targeted support for several debilitating symptoms associated with complex chronic illnesses: Profound Fatigue and Post-Exertional Malaise (PEM): By artificially activating the AMPK pathway and providing the essential cofactors for the Krebs cycle, berberine and ALA help to bypass the metabolic bottlenecks that prevent cells from generating adequate ATP

doi: 10.3390/jpm12050721