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COP1 and DET1 cooperate to promote polyubiquitination of c-Jun The role of the RING finger in COP1 has been intriguing, as it can independently bind E2 enzymes 51,52 , making it appear as a redundant subunit within the CULLIN4 DET1-COP1 complex

Additional neurotrophic factors, including insulin-like growth factor 1 (IGF-1) and nerve growth factor (NGF), exert complementary effects by regulating cellular metabolism, promoting anti-apoptotic pathways, and enhancing myelination [239, 240]

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Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinsons disease

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