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The sixth coordination site, the reactive center, is variable, being a cyano group (CN), a hydroxyl group (OH), a methyl group (CH 3 ) or a 5-deoxyadenosyl group

Ethics declarations Competing interests J.J.N

Contribution statement MA contributed to the generation of the results and analysis using the TriNetX platform and took the lead on writing the manuscript

Metformin has been the backbone of Type 2 diabetes treatment for decades, and it remains the recommended starting point in most guidelines

For anyone trying to lose weight, especially when traditional methods like diet and exercise havent been enough, choosing the right treatment is essential