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A proteolysis-resistant MRI-visible nanoparticle formulation of GLP-1RA (nano-GLP-1RA) was engineered to target GLP-1Rexpressing cells within atherosclerotic lesions ( In ApoE/ mice, nano-GLP-1RA selectively accumulated in plaque-resident inflammatory and de-differentiated smooth muscle cells, consistent with GLP-1Rexpressing populations observed in human plaques ( Taken together, while imaging and omics technologies offer powerful tools to characterize vascular biology, their integration with GLP-1RA therapy for patient stratification remains an emerging concept that requires further clinical validation
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It is a naturally occurring antioxidant valued for its health benefits
Nutrients 16(12):1860
Further characterization of the human commensals capable of both reactions (l-carnitineBB and BBTMA), and discovery of the enzyme(s) responsible for TMA production, are of interest particularly since this latter microbial step in the overall pathway appears to be the major one induced during chronic dietary red meat exposure (or directly with l-carnitine supplementation) in an omnivorous diet (Figure 10)
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