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Chronic inflammation degrades the extracellular matrix, disrupts collagen architecture, and impairs the skin barrier function

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This process disrupts the structure of cell membranes and initiates ferroptosis through the Fenton reaction (Yu et al., 2019), observed that transferrin receptor (TFRC) expression was significantly higher in ER-tissues compared to ER + tissues, and knockdown of estrogen receptor (ER) increased TFRC expression in BC cells

Mackenzie, G