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In the derived splenocytes, resveratrol (10, 30 M) reduced the induction of CD25+ cells, IL-2, IL-4, IL-13 and IFN- associated with inhibition of GATA-3 and T-bet, suggested to be achieved through inhibition of dendritic cell maturation via co-stimulatory molecule CD80 and CD86 expression, and consequential early T cell activation and differentiation by repression of cyclic adenosine monophosphate (cAMP) activation of bone marrow derived dendritic cells [184]