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Although the specificity is higher, the sensitivity is lower than that of EIAs.1,16 The rational in accepting a test with a lower sensitivity to confirm another test with higher sensitivity was object of controversy
Unfortunately, this conventional clinical strategy sheds little light on the underlying infertility etiology or the functional integrity of a patients spermatozoa and has thus proven to be of limited utility in predicting fertilization success ( via the coupling of ultra-high magnification with machine learning [i.e., motile sperm organelle morphology examination (MSOME)], with the goal of standardizing the detection of morphological anomalies, it remains uncertain which elements of sperm structure define the functionality of this highly specialized cell
High rates of attrition (12%) were observed in Altimmunes trials, and 5% of patients on semaglutide discontinued treatment due to nausea, vomiting or diarrhea (with 25-44% of patients reporting symptoms)
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