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Fifth, the inclusion of both RCTs and observational studies introduces potential bias due to differences in design, particularly confounding and selection bias in observational data, which may distort pooled effect estimates

Males were dosed for 4 weeks prior to mating, and females were dosed for 2 weeks prior to mating and throughout organogenesis until Gestation Day 17

These work by mimicking a natural hormone that: Reduces appetite and targets brain regions involved in appetite regulation