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In late 2025, two Phase 3 trials of semaglutide in early Alzheimers disease missed their primary endpoint, despite years of encouraging epidemiology and biology

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Older adults may need dose adjustments or extra monitoring, especially if they have kidney problems or take other medicines

Study leader Venky Soundararajan of data analytics firm nference said the findings raise the hypothesis that GLP-1 drugs may be acting directly on the heart, though he characterized it as a hypothesis requiring further experimental investigation

Muscle mass naturally declines with age unless it is actively maintained