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In samples from IPF patients, we found significant upregulation of GPX3 in total tissue homogenates

Glutathione reductase activity is limiting in the matrix The experiments described above indicate that cytosolic redox enzymes significantly limit the amount of exogenous H 2 O 2 that reaches the mitochondrial matrix

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reported the therapeutic potential of another natural quinazoline derivative that promoted oxidative stress and increased ROS production [113]

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