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For instance, the heterogeneity among patients with Fabry disease, in terms of disease severity, specific GLA gene mutations, age, sex, and other individual health considerations, may lead to differing immune responses even in individuals with the same disease

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In contrast to the centrally-located macula, rich in cone cells and therefore best adapted for high acuity vision resolution, the rest of the peripheral retina has much poorer ability to detect images with high acuity (Yanoff 2011)